HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxolan-3-amine → 2-[2-(3-Butyl-5-methyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (tetrahydro-furan-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxolan-3-amine | HCID 3365553 | — |
| Reactant | HCID 66643644 | HCID 66643644 | — |
| Product | 2-[2-(3-Butyl-5-methyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (tetrahydro-furan-3-yl)-amide | HCID 49782277 | 71% |
Reaction Steps
As described for example 57b, 2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid methyl ester (90 mg, 0.29 mmol) was converted, using tetrahydrofuran-3-amine instead of isopropylamine, to the title compound (45 mg, 71%) which was obtained as a light yellow oil. MS: m/e=364.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-feae6c6a08a942a39d086386bb4720cc |
| Source note | uspto-grants-2012_05 |