HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-oxolan-3-amine hydrochloride → (s)-2-[(e)-2-(5-Methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid (tetra-hydro-furan-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-oxolan-3-amine hydrochloride | HCID 18664284 | — |
| Reactant | HCID 66643683 | HCID 66643683 | — |
| Product | (s)-2-[(e)-2-(5-Methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid (tetra-hydro-furan-3-yl)-amide | HCID 131729716 | 89% |
Reaction Steps
As described for example 63b, 2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid ethyl ester (50 mg, 0.15 mmol) was converted, using (S)-tetrahydrofuran-3-amine HCl instead of 4-aminotetrahydropyran, to the title compound (50 mg, 89%) which was obtained as a white solid. MS: m/e=382.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-983a67e109694fd49438ead22866d13b |
| Source note | uspto-grants-2012_05 |