反应详情

As described for example 66, 4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid methyl ester (55 mg, 0.17 mmol) was converted, using ethanolamine instead of rac-2-amino-1-propanol, to the title compound (34 mg, 63%) which was obtained as a light yellow solid. MS: m/e=356.2 [M+H]+.