Oxolan-3-amine → HCID 46944264, compound

HRID 1923569Notes

Reaction equation

HRID 1923569 reaction equation
CO[C:3]([C:5]1[S:9][C:8](/[CH:10]=[CH:11]/[C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:14][O:15][C:16]=2[CH3:17])=[N:7][C:6]=1[CH3:24])=[O:4].[NH2:25][CH:26]1[CH2:30][CH2:29][O:28][CH2:27]1>>[O:28]1[CH2:29][CH2:30][CH:26]([NH:25][C:3]([C:5]2[S:9][C:8](/[CH:10]=[CH:11]/[C:12]3[C:13]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)=[N:14][O:15][C:16]=3[CH3:17])=[N:7][C:6]=2[CH3:24])=[O:4])[CH2:27]1

Participants

3

Reactant 2

HCID 3365553Oxolan-3-amineHCID 66643663HCID 66643663, compound

Product 1

HCID 46944264HCID 46944264, compoundYield 43%

Procedure

As described for example 68c, 4-methyl-2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid methyl ester (80 mg, 0.24 mmol) was converted, using 3-amino-tetrahydrofuran instead of isopropylamine, to the title compound (40 mg, 43%) which was obtained as a light yellow solid. MS: m/e=396.3 [M+H]+.

Sources & evidence

ORD record
ord-6fb0f9460d08483fa3bae08765f0f4ff
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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