HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 2-{(E)-2-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl}-vinyl]-thiazole-5-carboxylic acid isopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 2-{(E)-2-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-vinyl}-thiazole-5-carboxylic acid | HCID 66643610 | — |
| Product | 2-{(E)-2-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl}-vinyl]-thiazole-5-carboxylic acid isopropylamide | HCID 59568530 | 59% |
Reaction Steps
As described for example 77c, 2-{(E)-2-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-vinyl}-thiazole-5-carboxylic acid (83 mg, 0.25 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (55 mg, 59%) which was obtained as an off white solid after recrystallization from heptane/ethyl acetate. MS: m/e=373.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-81f900750aac4d308723634d74c18404 |
| Source note | uspto-grants-2012_05 |