Cyclopropanemethanamine → HCID 59568503, compound

Participants

Reaction Steps

As described for example 90 g, 2-{(E)-2-[3-(5-fluoro-pyridin-2-yl)-isoxazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid (99 mg, 0.3 mmol) was converted, using aminomethylcyclopropane instead of 4-aminotetrahydropyran, to the title compound (51 mg, 44%) which was obtained as an off white solid after purification by chromatography (silica, 0 to 100% ethyl acetate in heptane) and recrystallization from heptane/ethyl acetate. MS: m/e=385.1 [M+H]+.

Provenance & Evidence