HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxolan-3-amine → 2-[(E)-2-(3-Butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid (tetrahydro-furan-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxolan-3-amine | HCID 3365553 | — |
| Reactant | 2-[(E)-2-(3-Butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid methyl ester | HCID 66643651 | — |
| Product | 2-[(E)-2-(3-Butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid (tetrahydro-furan-3-yl)-amide | HCID 49781150 | 46% |
Reaction Steps
As described for example 93d, 2-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid methyl ester (80 mg, 0.25 mmol) was converted, using 3-amino-tetrahydrofuran instead of isopropylamine, to the title compound (43 mg, 46%) which was obtained as a white solid. MS: m/e=376.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4dd4b47caf1741bcb18fa3c66ada270d |
| Source note | uspto-grants-2012_05 |