反应详情

To a stirred solution of 2-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid methyl ester (70 mg, 0.22 mmol) in toluene (0.5 mL) was added ethanolamine (16 mg, 0.26 mmol) and TBD (18 mg, 0.12 mmol). After 20 h the reaction mixture was concentrated in vacuo then purified by chromatography (silica, 0 to 10% methanol in dichloromethane) to give the title compound (14 mg, 18%) as a white solid. MS: m/e=350.3 [M+H]+.

1. concentrationAfter 20 h the reaction mixture was concentrated in vacuo
2. customthen purified by chromatography (silica, 0 to 10% methanol in dichloromethane)