HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyazetidine hydrochloride → HCID 49780484, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyazetidine hydrochloride | HCID 22242858 | — |
| Reactant | 2-[(E)-2-(3-Butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid | HCID 59568539 | — |
| Product | HCID 49780484 | HCID 49780484 | 24% |
Reaction Steps
As described for example 108, 2-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid (200 mg, 0.65 mmol) was converted, using 3-methoxy-azetidine hydrochloride instead of 3,3-difluoroazetidine hydrochloride, to the title compound (58 mg, 24%) which was obtained as a light yellow oil. MS: m/e=376.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d7a8cab1cba94f1d95a7993efc4325e9 |
| Source note | uspto-grants-2012_05 |