(1R,2R)-2-aminocyclopentan-1-ol hydrochloride → HCID 86647274, compound

Participants

Reaction Steps

As described for example 104, 2-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid (153 mg, 0.5 mmol) was converted, using trans-(−)-2-aminocyclopentanol hydrochloride instead of rac-2-amino-1-butanol, to the title compound (146 mg, 75%) which was obtained as an off white solid after purification by chromatography (silica, 50 to 100% ethyl acetate in heptane) and recrystallization from ethyl acetate/heptane. MS: m/e=390.3 [M+H]+.

Provenance & Evidence