Ethanolamine → 2-[(E)-2-(3-Butyl-5-methyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide

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Reaction Steps

As described for example 124b, 2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-2-hydroxy-ethyl]-thiazole-5-carboxylic acid methyl ester (90 mg, 0.29 mmol) was converted, using ethanolamine instead of isopropylamine, to the title compound (35 mg, 35%) which was obtained as a light yellow solid after purification by chromatography (silica, 0 to 10% methanol in dichloromethane). MS: m/e=336.3 [M+H]+.

Provenance & Evidence