HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminotetrahydropyran → 2-Chloro-N-(tetrahydro-2H-pyran-4-yl)thiazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | Ethyl 2-chloro-1,3-thiazole-5-carboxylate | HCID 19017727 | — |
| Product | 2-Chloro-N-(tetrahydro-2H-pyran-4-yl)thiazole-5-carboxamide | HCID 66643757 | 73% |
Reaction Steps
As described for example 135a, 2-chloro-thiazole-5-carboxylic acid ethyl ester (500 mg, 2.6 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (471 mg, 73%) which was obtained as a white solid after purification by chromatography (silica, 0 to 3% methanol in dichloromethane). MS: m/e=247.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-0c1aff949bc64a678c7b9ccbdab7d3c8 |
| Source note | uspto-grants-2012_05 |