Hydrochloric Acid → HCID 40427065, compound

Participants

Reaction Steps

To a solution of (2S)-2-amino-3-(pyridin-4-yl)propanoic acid LXXIII (660 mg, 4.0 mmol) in ethanol (120 mL) was added 1 N HCl (10 mL) and PtO2 (150 mg). The mixture was vigorously shaken 70 psi H2 in a Parr apparatus for 48 h. The mixture was filtered through Celite and the filtrate was concentrated to dryness giving crude (2S)-2-amino-3-(piperidin-4-yl)propanoic acid LXXIV as the hydrochloride salt (988 mg). ESIMS found for C8H16NO2 m/z 172.0 (M+).

Provenance & Evidence