Sodium Hydroxide → HCID 59367312, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[(2S)-2-azido-2-[(quinolin-3-yl)carbamoyl]ethyl]piperidine-1-carboxylate LXXVIII (262 mg, 0.62 mmol) in THF (20 mL) and 0.1 M NaOH (2.0 mL) was added Me3P (1 M in THF, 0.65 mL). The reaction was stirred at r.t. overnight. The solvent was removed under reduced pressure to give crude tert-butyl 4-[(2S)-2-amino-2-[(quinolin-3-yl)carbamoyl]ethyl]piperidine-1-carboxylate LXXIX (275 mg), which was directly used in step 8. ESIMS found for C22H30N4O3 m/z 399 (M+H).

Provenance & Evidence