HCID 59366875, compound → HCID 59367253, compound

Participants

Reaction Steps

To a solution of tert-butyl N-[(1S)-4-(3-{[(benzyloxy)carbonyl]amino}pyrrolidin-1-yl)-1-{[(1R)-1-[(quinolin-3-yl)carbamoyl]-2-[4-(trifluoromethyl)phenyl]ethyl]carbamoyl}butyl]carbamate CXIII (170 mg, 0.22 mmol) in methanol (20 mL) was added catalytic amount of 10% Pd/C catalyst. The mixture was hydrogenated at normal pressure for 48 h. The catalyst was filtered through Celite and the filtrate was concentrated to give tert-butyl N-[(1S)-4-(3-aminopyrrolidin-1-yl)-1-{[(1R)-1-[(quinolin-3-yl)carbamoyl]-2-[4-(trifluoromethyl)phenyl]ethyl]carbamoyl}butyl]carbamate CXIV (120 mg, 0.19 mmol, 86.4% yield). ESIMS found for C33H41N6O4F3 m/z 643 (M+H).

Provenance & Evidence