HCID 67521556, compound → HCID 86643248, compound

Participants

Reaction Steps

N-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)-3-nitro[1,5]naphthyridin-4-amine (2.36 g, 6.78 mmol) was dissolved in 50 mL of acetonitrile and the solution was placed in a pressure bottle. Platinum on carbon (5%, 200 mg) was then added and the reaction mixture was shaken under H2 at 50 PSI (3.4×105 Pa). After 3 hours, the reaction mixture was filtered through a pad of CELITE filter agent. The pad was rinsed with acetonitrile and the combined filtrates were concentrated under reduced pressure to give 2.12 g of N4-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)[1,5]naphthyridine-3,4-diamine as an orange solid.

Provenance & Evidence