HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Xylene → 6-Methyl-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | N-(2-chloro-5-methylpyridin-3-yl)-2-nitrobenzamide | HCID 15654865 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6-Methyl-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine | HCID 59679858 | 75.4% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
A mixture of N-(2-chloro-5-methylpyridin-3-yl)-2-nitrobenzamide (5.0 g, 17.1 mmol) and P2S5 (7.6 g, 34.2 mmol) in pyridine (50 mL) and p -xylene (200 mL) was stirred at 140° C. for 20 h. The hot solution was transferred to another flask and the solvent was removed in vacuo. The residue was purified by recrystallization from EtOH to afford 6-methyl-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine as a yellow solid (3.5 g, yield: 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178536B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b6ca0cd18df94e86b573f3f36a4699ed |
| Source note | uspto-grants-2012_05 |