4-Iodobenzenesulfonyl chloride → HCID 25012074, compound

Participants

Reaction Conditions

Reaction Steps

Pyrimidin-4-yl-methylamine dihydrochloride (1.0 eq) and triethylamine (3.0 eq) were dissolved in acetonitrile (5 mL/mmol) and the solution was cooled to 0° C. 4-Iodobenzenesulfonic acid chloride (1.0 eq) was added in portions and the reaction mixture was warmed to room temperature. The solvent was evaporated under reduced pressure and the residue was washed with cold water and cold diisopropyl ether to yield the title compound as beige solid.

Provenance & Evidence