HCID 57743078, compound → HCID 15979331, compound

HRID 1924254Notes

Reaction equation

HRID 1924254 reaction equation
[CH:1]([C:3]1[N:7]([CH3:8])[CH:6]=[N:5][C:4]=1[C:9]#[N:10])=O.Cl.[NH2:12][CH2:13][CH:14]([C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:22]=1[F:29])[CH2:15][C:16](OCC)=[O:17]>>[CH3:8][N:7]1[C:3]([CH2:1][N:12]2[CH2:13][CH:14]([C:21]3[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:22]=3[F:29])[CH2:15][C:16]2=[O:17])=[C:4]([C:9]#[N:10])[N:5]=[CH:6]1

Participants

3

Reactant 2

HCID 57743078HCID 57743078, compoundHCID 86631465HCID 86631465, compound

Product 1

HCID 15979331HCID 15979331, compoundYield 25.8%

Procedure

1-methyl-5-{[2-oxo-4-(2,3,5-trifluorophenyl)pyrrolidin-1-yl]methyl}-1H-imidazole-4-carbonitrile 127 is prepared according to the method described in 10.1 starting from 5-formyl-1-methyl-1H-imidazole-4-carbonitrile x86 and ethyl 4-amino-3-(2,3,5-trifluorophenyl)butanoate hydrochloride x60.

Sources & evidence

ORD record
ord-894c930dd8c745ffa599aeab173c1c66
Source dataset
uspto-grants-2012_05
Patent number
US08178533B2

Reaction notes

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