HCID 53629172, compound → HCID 15979803, compound

HRID 1924307Notes

Reaction equation

HRID 1924307 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[NH:10][C:9]([CH:11]3[CH2:13][CH2:12]3)=[N:8][C:5]2=[N:6][CH:7]=1.[F:14][C:15]([F:25])=[CH:16][CH:17]1[CH2:21][N:20]([CH2:22]O)[C:19](=[O:24])[CH2:18]1>>[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([CH:11]3[CH2:13][CH2:12]3)[N:8]([CH2:22][N:20]3[CH2:21][CH:17]([CH:16]=[C:15]([F:25])[F:14])[CH2:18][C:19]3=[O:24])[C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 53629172HCID 53629172, compoundHCID 53629179HCID 53629179, compound

Product 1

HCID 15979803HCID 15979803, compoundYield 25%

Procedure

1-[(6-bromo-2-cyclopropyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-4-(2,2-difluorovinyl)pyrrolidin-2-one 272 is synthesized according to the procedure described in example 61 using 6-bromo-2-cyclopropyl-1H-imidazo[4,5-b]pyridine x168 and 4-(2,2-difluorovinyl)-1-(hydroxymethyl)pyrrolidin-2-one x142.

Sources & evidence

ORD record
ord-7b83223c3fb84087be60cf68d26983eb
Source dataset
uspto-grants-2012_05
Patent number
US08178533B2

Reaction notes

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