HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 57743023, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 57743074 | HCID 57743074 | — |
| Reactant | HCID 57743081 | HCID 57743081 | — |
| Product | HCID 57743023 | HCID 57743023 | 45.3% |
Reaction Steps
This step is realized as described in example 68.5. for the synthesis of [3-(4-methoxybenzyl)-3H-imidazo[4,5-b]pyridin-7-yl]methanol x183 with the use of 3 eq of NaBH4 for 1.45 g (3.8 mmol) of ethyl 3-(4-methoxybenzyl)-5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine-7-carboxylate x196. Purification by chromatography on silicagel affords 0.58 g of [3-(4-methoxybenzyl)-5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-7-yl]methanol x199.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178533B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b9e6bb1e82774de2be1f2a81070803e3 |
| Source note | uspto-grants-2012_05 |