Carbamic acid, N-[(1R,2S)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethenylcyclopropyl]-, 1,1-dimethylethyl ester → HCID 70324238, compound

Participants

Reaction Steps

A hydrogenation vessel was charged with a solution of tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate (prepared as described in WO 03/099274) followed by Ru/C (7.5 wt %). The vessel was placed under N2 (20 psig) and vented to atmospheric pressure three times to remove residual oxygen. The vessel was then placed under H2 (50 psig) and the reaction was complete in <5 h based on H2 consumption. After 20 h, the vessel was vented to atmospheric pressure. The reaction slurry was then transferred out of the reaction vessel, filtered and evaporated to a yellow oil which was brought to the following step without further purification. MS (ES+) C14H24BN2O5S requires 332. Found: 333 (M+H+).

Provenance & Evidence