HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 44550117, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Boc-L-Valine | HCID 83693 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 86635050 | HCID 86635050 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44550117 | HCID 44550117 | — |
Reaction Steps
To a solution of Intermediate 1 in DMF was added Boc-(L)-Val (1.05 eq), followed by iPr2NEt (3.5 eq) and TBTU (1.05 eq). The resulting reaction mixture was stirred 12 h at RT and partitioned between EtOAc and 1N aq. HCl. The organic layer was further washed with sat. aq. NaHCO3, brine, dried (Na2SO4) and concentrated under reduced pressure. The residue was purified by SiO2 gel chromatography (hexane/EtOAc=7/3) to give the title compound as a colourless oil. MS (ES+) C27H35N3O6 requires: 497. Found: 498 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178520B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-6af3de9a87dd4bae96ef8393368673fc |
| Source note | uspto-grants-2012_05 |