Piperidine → HCID 44549611, compound

Participants

Reaction Steps

iPr2NEt (2 eq) was added to a suspension of hydrochloride from Step 2 in DCM at 0° C., and the resulting clear solution was immediately added to a solution of FMOC-isothiocyanate (1.1 eq) in DCM at 0° C. The resulting mixture was stirred at RT for 30 min and then treated with a 20% solution of piperidine in MeOH. After 3 h, the volatiles were removed under reduced pressure and the residue was purified by SiO2 gel chromatography (gradient elution, hexane/EtOAc=8/2 to DCM/MeOH=95/5) to give the title compound as a pale yellow foam. MS (ES+) C23H28N4O4S requires: 456. Found: 457 (M+H+).

Provenance & Evidence