2-(Chloromethyl)-4-methylquinazoline → HCID 66753209, compound

HRID 1924391Notes

Reaction equation

HRID 1924391 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:12]Cl)[N:3]=1.[CH3:14][N:15]1[C:23]2[N:22]=[C:21](Br)[N:20]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[Cl:32])[C:19]=2[C:18](=[O:33])[NH:17][C:16]1=[O:34].[C:35]([O:39][C:40]([NH:42][C@@H:43]1[CH2:48][CH2:47][CH2:46][NH:45][CH2:44]1)=[O:41])([CH3:38])([CH3:37])[CH3:36]>>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:12][N:17]2[C:18](=[O:33])[C:19]3[N:20]([CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[Cl:32])[C:21]([N:45]4[CH2:46][CH2:47][CH2:48][C@@H:43]([NH:42][C:40]([O:39][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:41])[CH2:44]4)=[N:22][C:23]=3[N:15]([CH3:14])[C:16]2=[O:34])[N:3]=1

Participants

4

Reactant 3

HCID 2415182-(Chloromethyl)-4-methylquinazolineHCID 649688HCID 649688, compoundHCID 1514172(3R)-3-Aminopiperidine, 3-BOC protected

Product 1

HCID 66753209HCID 66753209, compound

Procedure

Prepared by reacting (4-methyl-quinazolin-2-yl)-methylchloride and 3-methyl-7-(2-chlorobenzyl)-8-bromo-xanthine and subsequently reacting with (R)-3-(tert.-butyloxycarbonylamino)-piperidine

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3e4d3b31176c463d845372dec2f72700
Source dataset
uspto-grants-2012_05
Patent number
US08178541B2

Reaction notes

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