HCID 649688, compound → HCID 66753678, compound

HRID 1924392Notes

Reaction equation

HRID 1924392 reaction equation
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:9]([CH2:17]Cl)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][N:20]1[C:28]2[N:27]=[C:26](Br)[N:25]([CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[Cl:37])[C:24]=2[C:23](=[O:38])[NH:22][C:21]1=[O:39].[C:40]([O:44][C:45]([NH:47][C@@H:48]1[CH2:53][CH2:52][CH2:51][NH:50][CH2:49]1)=[O:46])([CH3:43])([CH3:42])[CH3:41]>>[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:9]([CH2:17][N:22]3[C:23](=[O:38])[C:24]4[N:25]([CH2:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=5[Cl:37])[C:26]([N:50]5[CH2:51][CH2:52][CH2:53][C@@H:48]([NH:47][C:45]([O:44][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:46])[CH2:49]5)=[N:27][C:28]=4[N:20]([CH3:19])[C:21]3=[O:39])[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 649688HCID 649688, compoundHCID 1514172(3R)-3-Aminopiperidine, 3-BOC protectedHCID 110971482-(chloromethyl)-4-phenylquinazoline

Product 1

HCID 66753678HCID 66753678, compound

Procedure

Prepared by reacting (4-phenyl-quinazolin-2-yl)-methylchloride and 3-methyl-7-(2-chlorobenzyl)-8-bromo-xanthine and subsequently reacting with (R)-3-(tert.-butyloxycarbonylamino)-piperidine

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fce0c67f146f414da412c9fda28c3978
Source dataset
uspto-grants-2012_05
Patent number
US08178541B2

Reaction notes

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