反应详情

A mixture of 829 mg of 1-methyl-7-(2-cyano-benzyl)-8-chloro-xanthine, 640 mg of phenylboric acid, 509 mg of anhydrous copper acetate and 0.43 ml of pyridine in 20 ml methylene chloride is stirred for four days at ambient temperature in the presence of 100 mg of 4 Å molecular sieves. Then another 320 mg of phenylboric acid are added and the reaction mixture is stirred for another day at ambient temperature. For working up the mixture is filtered through talc and washed with ethyl acetate. The filtrate is evaporated down and chromatographed through a silica gel column with cyclohexane/ethyl acetate (7:3 to 1:1) as eluant.

1. stirringthe reaction mixture is stirred for another day at ambient temperature
2. filtrationis filtered through talc
3. washwashed with ethyl acetate
4. customThe filtrate is evaporated down
5. customchromatographed through a silica gel column with cyclohexane/ethyl acetate (7:3 to 1:1) as eluant