HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-Amino-2-mercapto-3H-quinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Benzoic acid, 2-isothiocyanato-, methyl ester | HCID 85243 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Amino-2-mercapto-3H-quinazolin-4-one | HCID 726383 | 96% |
Reaction Steps
Methyl 2-isothiocyanatobenzoate (5.00 g, 25.9 mmol) was dissolved in THF (125 mL), followed by addition of hydrazine monohydrate (2.51 mL, 51.8 mmol). The reaction mixture was refluxed for 1 h, cooled to RT and the precipitate was collected by filtration. The precipitate was washed with water and dried in vacuo to give pure title compound (4.78 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178544B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-be37bae17a0448bfa4b1b83fca698439 |
| Source note | uspto-grants-2012_05 |