Tetrabutylammonium Fluoride → HCID 67521035, compound

Participants

Reaction Steps

N-[6-(tert-Butyl-dimethyl-silanyloxy)-2-diethylamino-4-oxo-4H-quinazolin-3-yl]-2-(3,5-difluoro-phenyl)-acetamide (1.50 g, 2.85 mmol) was dissolved in dry THF (50 mL). Tetrabutylammonium fluoride (1 M in THF, 3.13 mL, 3.13 mmol) was added to the mixture over 10 minutes at RT. Stirring was continued for 30 minutes. The solvent was removed in vacuo and the residue was subjected to column chromatography (EtOAc/Heptane) giving the title compound (0.60 g, 54%).

Provenance & Evidence