HCID 67519206, compound → HCID 67519178, compound

Participants

Reaction Steps

(+)-[N-(Benzyloxycarbonyl)morphinan-3-yloxy]methyl isobutyrate (4.12 g, 8.63 mmol) from Example 44 was subjected to hydrogenation (balloon) on 10% Pd/C (600 mg) in EtOH (100 mL) at room temperature. After the reaction was completed, the reaction mixture was filtered through a Celite, and washed with EtOH (300 mL). The combined EtOH solution was evaporated under vacuum. The residue was further purified by reverse-phase prep HPLC to provide the title compound (1.11 g, 37%) as a light yellow gum.

Provenance & Evidence