Iodine → HCID 59238645, compound

Participants

Reaction Steps

To a stirred solution of the azaindole (XIb-19) (2.51 g, 9.72 mmol) in DMF (40 mL), was added crushed KOH pellets (2.05 g, 36.6 mmol) followed by I2 (2.22 g, 8.7 mmol). The mixture was stirred at room temperature for 3.5 h and concentrated in vacuum. The residue was partitioned between EtOAc (100 mL) and saturated aqueous NaHCO3 solution (40 mL). The aqueous layer was extracted with EtOAc (3×60 mL). The combined organic solutions were dried (MgSO4), filtered and concentrated. The residue consisting of crude iodide (XIIb-19) was used for the preparation of (IXb-19) without any additional purification.

Provenance & Evidence