1,3-Benzodioxol-5-ylhydrazine → 3-(2-Benzo[1,3]dioxol-5-yl-2H-pyrazol-3-yl)-1-phenyl-1H-pyridazin-4-one

Participants

Reaction Steps

3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) (0.2 g; 0.74 mmol) and 3,4-methylenedioxyphenylhydrazine (0.136 g; 0.89 mmol) are dissolved in a sealed tube in acetic acid (4 ml) and irradiated at 180° C. for 10 min. The solvent of the reaction mixture is removed and the crude product is purified by preparative HPLC yielding 0.80 g (30%) of the final product. MS: M=359.0 (M+H)+

Provenance & Evidence