HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluorophenylhydrazine → 3-[2-(2,5-Difluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluorophenylhydrazine | HCID 588957 | — |
| Reactant | 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one | HCID 59370027 | — |
| Product | 3-[2-(2,5-Difluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one | HCID 46219579 | 32% |
Reaction Steps
The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one (A-3) and 2,5-difluorophenylhydrazine according to the method described for Example 1 in 32% yield. MS: M=419.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d8a34ad08cd349fc9ada2d7bddaacd9b |
| Source note | uspto-grants-2012_05 |