(2,5-Dichlorophenyl)hydrazine → 3-[2-(2,5-Dichloro-phenyl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-one

HRID 1924493Notes

Reaction equation

HRID 1924493 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=O.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=1[NH:29]N>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=1[N:29]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 9366(2,5-Dichlorophenyl)hydrazineHCID 12742246(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-one

Product 1

HCID 462194513-[2-(2,5-Dichloro-phenyl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-oneYield 23%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) and 2,5-dichlorophenylhydrazine according to the method described for Example 1 in 23% yield. MS: M=383.0 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-036b5f3231cc479ba1cb090fbc376676
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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