4-Hydrazinopyridine → 1-(3-Ethyl-phenyl)-3-(2-pyridin-4-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-one

HRID 1924501Notes

Reaction equation

HRID 1924501 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][CH3:21])[CH:15]=2)[N:8]=1)=O.[NH:23]([C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1)N>>[CH2:20]([C:16]1[CH:15]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:23]([C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=1)[CH3:21]

Participants

3

Reactant 2

HCID 4166314-HydrazinopyridineHCID 593701083-((E)-3-Dimethylamino-acryloyl)-1-(3-ethyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462195741-(3-Ethyl-phenyl)-3-(2-pyridin-4-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-oneYield 47%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-ethyl-phenyl)-1H-pyridazin-4-one (A-4) and 4-hydrazinopyridine according to the method described for Example 1 in 47% yield. MS: M=344.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-72ba1905c0e84c76b6b6ffca747cc622
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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