2-Fluorophenylhydrazine hydrochloride → 3-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

HRID 1924512Notes

Reaction equation

HRID 1924512 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[N:8]=1)=O.[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[NH:33]N>>[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[N:33]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:15]=[CH:16][C:17]([O:20][C:21]([F:22])([F:23])[F:24])=[CH:18][CH:19]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 4238442-Fluorophenylhydrazine hydrochlorideHCID 593700343-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462198143-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-oneYield 65%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-8) and 2-fluoro-phenylhydrazine according to the method described for Example 1 in 65% yield. MS: M=417.0 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-78c9bf6facbf4978b6535668900a3553
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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