3-Hydrazinylbenzonitrile → 3-{5-[4-Oxo-1-(4-trifluoromethoxy-phenyl)-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzonitrile

HRID 1924513노트

반응식

HRID 1924513 반응식
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[N:8]=1)=O.[NH:26]([C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)[C:31]#[N:32])[NH2:27]>C(O)C>[O:13]=[C:12]1[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[CH:16][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:18][CH:19]=2)[N:8]=[C:7]1[C:5]1[N:26]([C:28]2[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=2)[C:31]#[N:32])[N:27]=[CH:3][CH:4]=1

참가 물질

4

반응물 2

HCID 14881453-HydrazinylbenzonitrileHCID 593700343-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

생성물 1

HCID 462202543-{5-[4-Oxo-1-(4-trifluoromethoxy-phenyl)-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzonitrile수율 21%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-8) and 3-hydrazino-benzonitrile in ethanol as solvent according to the method described for Example 1 in 21% yield. MS: M=424.1 (M+H)+

후처리

  1. customThe product was obtained

출처 및 근거

ORD 기록
ord-37d6397238384a0a94c226078c7f93d5
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178538B2

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