2-Fluorophenylhydrazine hydrochloride → 3-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one

HRID 1924514Notes

Reaction equation

HRID 1924514 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[N:8]=1)=O.[F:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH:32]N>>[F:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[N:32]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 4238442-Fluorophenylhydrazine hydrochlorideHCID 593700273-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462198163-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-oneYield 57%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one (A-3) and 2-fluoro-phenylhydrazine according to the method described for Example 1 in 57% yield.

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-ddd7286661364891908b084dee6dfd20
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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