反应详情

3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and 3-hydrazino-benzamide (2 eq) were dissolved in a sealed tube in acetic acid and irradiated in MW at 120° C. for 15 min. The solvent of the reaction mixture was removed and the crude product was purified by preparative HPLC yielding the desired product.

1. customirradiated in MW at 120° C. for 15 min
2. customThe solvent of the reaction mixture was removed
3. customthe crude product was purified by preparative HPLC