3-Hydrazinylbenzamide → HCID 46219931, compound

HRID 1924520Notes

Reaction equation

HRID 1924520 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=1)=O.[NH:26]([C:28]1[CH:29]=[C:30]([CH:34]=[CH:35][CH:36]=1)[C:31]([NH2:33])=[O:32])N>C(O)(=O)C>[O:13]=[C:12]1[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=[C:7]1[C:5]1[N:26]([C:28]2[CH:29]=[C:30]([CH:34]=[CH:35][CH:36]=2)[C:31]([NH2:33])=[O:32])[N:2]=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 156783373-HydrazinylbenzamideHCID 593701233-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 46219931HCID 46219931, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and 3-hydrazino-benzamide (2 eq) were dissolved in a sealed tube in acetic acid and irradiated in MW at 120° C. for 15 min. The solvent of the reaction mixture was removed and the crude product was purified by preparative HPLC yielding the desired product.

Workup

  1. customirradiated in MW at 120° C. for 15 min
  2. customThe solvent of the reaction mixture was removed
  3. customthe crude product was purified by preparative HPLC

Sources & evidence

ORD record
ord-62a55a25795e41dd96a5e9f1def94c2f
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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