(2-Bromo-4-fluorophenyl)hydrazine → HCID 46220148, compound

HRID 1924529Notes

Reaction equation

HRID 1924529 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=1)=O.[Br:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[NH:34]N>>[Br:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[N:34]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 1381943(2-Bromo-4-fluorophenyl)hydrazineHCID 593701233-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 46220148HCID 46220148, compound

Procedure

Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and (2-bromo-4-fluoro-phenyl)-hydrazine according to example 43 gave the desired product. MS: M=496.9 (M+H)+

Sources & evidence

ORD record
ord-e8d1c97379744f21afd4a663cd54a18c
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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