HCID 55279166, compound → HCID 59370117, compound

HRID 1924533Notes

Reaction equation

HRID 1924533 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=1)=O.[CH2:26]([O:28][C:29](=[O:38])[C:30]1[CH:35]=[CH:34][N:33]=[C:32]([NH:36]N)[CH:31]=1)[CH3:27]>>[CH2:26]([O:28][C:29](=[O:38])[C:30]1[CH:35]=[CH:34][N:33]=[C:32]([N:36]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:2]2)[CH:31]=1)[CH3:27]

Participants

3

Reactant 2

HCID 55279166HCID 55279166, compoundHCID 593701233-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 59370117HCID 59370117, compound

Procedure

Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and 2-hydrazino-isonicotinic acid ethyl ester (described in Anales Real Soc. Espan. Fis. Quire. (Madrid) Ser. B (1963), 59(3), 179-84) according to example 43 gave the desired product. MS: M=454.0 (M+H)+

Sources & evidence

ORD record
ord-a464c0b8cbcc44618853e8ddec2bcf47
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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