HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 1-(3-Methanesulfonyl-phenyl)-3-[2-(5,6,7,8-tetrahydro-isoquinolin-1-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5,6,7,8-Tetrahydroisoquinolin-1-amine | HCID 15871186 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | (5,6,7,8-Tetrahydro-isoquinolin-1-yl)-hydrazine | HCID 55281931 | — |
| Reactant | 3-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one | HCID 59370171 | — |
| Product | 1-(3-Methanesulfonyl-phenyl)-3-[2-(5,6,7,8-tetrahydro-isoquinolin-1-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one | HCID 59370002 | — |
Reaction Steps
Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-7) and (5,6,7,8-tetrahydro-isoquinolin-1-yl)-hydrazine (prepared from the commercial 5,6,7,8-tetrahydro-isoquinolin-1-ylamine using sodium nitrite and tin(II) chloride in analogy to that described in J. Med. Chem. 2003, 46, 4676-4686) according to example 43 gave the desired product. MS: M=448.0 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9438331f3fe644618ce83c76aa321e2a |
| Source note | uspto-grants-2012_05 |