(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-hydrazine → 3-[2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2H-pyrazol-3-yl]-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

HRID 1924556Notes

Reaction equation

HRID 1924556 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=1)=O.[O:26]1[C:31]2[CH:32]=[CH:33][C:34]([NH:36]N)=[CH:35][C:30]=2[O:29][CH2:28][CH2:27]1>>[O:26]1[C:31]2[CH:32]=[CH:33][C:34]([N:36]3[C:5]([C:7]4[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]5[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=5)[N:8]=4)=[CH:4][CH:3]=[N:2]3)=[CH:35][C:30]=2[O:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 5164485(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-hydrazineHCID 593701233-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593699953-[2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2H-pyrazol-3-yl]-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Procedure

Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and (2,3-dihydro-benzo[1,4]dioxin-6-yl)-hydrazine according to example 43 gave the desired product. MS: M=456.9 (M+H)+

Sources & evidence

ORD record
ord-dcf2fe5a135d4a368b24ba898c7849fe
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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