HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluorophenylhydrazine → 3-[2-(2,5-Difluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluorophenylhydrazine | HCID 588957 | — |
| Reactant | 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one | HCID 59370123 | — |
| Product | 3-[2-(2,5-Difluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one | HCID 59369999 | — |
Reaction Steps
Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and (2,5-difluoro-phenyl)-hydrazine according to example 43 gave the desired product. MS: M=435.0 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-3c712f2110904354955c845e367c9904 |
| Source note | uspto-grants-2012_05 |