(4-Isopropylphenyl)hydrazine → 3-[2-(4-Isopropyl-phenyl)-2H-pyrazol-3-yl]-1-(3-methanesulfonyl-phenyl)-1H-pyridazin-4-one

HRID 1924565Notes

Reaction equation

HRID 1924565 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[CH:25]([C:28]1[CH:33]=[CH:32][C:31]([NH:34]N)=[CH:30][CH:29]=1)([CH3:27])[CH3:26]>>[CH:25]([C:28]1[CH:33]=[CH:32][C:31]([N:34]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:2]2)=[CH:30][CH:29]=1)([CH3:27])[CH3:26]

Participants

3

Reactant 2

HCID 2733249(4-Isopropylphenyl)hydrazineHCID 593701713-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462190703-[2-(4-Isopropyl-phenyl)-2H-pyrazol-3-yl]-1-(3-methanesulfonyl-phenyl)-1H-pyridazin-4-one

Procedure

Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-7) and (4-isopropyl-phenyl)-hydrazine according to example 85 gave the desired product. MS: M=435.3 (M+H)+

Sources & evidence

ORD record
ord-56ca1ab998b345e4b8d87d66fbbbe9bc
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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