2-Hydrazinopyridine → 1-(3-Difluoromethoxy-phenyl)-3-(2-pyridin-2-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-one

Participants

Reaction Steps

1-(3-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-10) (0.05 g; 0.149 mmol) and 2-hydrazinopyridine (0.021 g; 0.194 mmol) are dissolved in a sealed tube in ethanol (0.6 ml) with catalytic amounts of HCl and irradiated at 160° C. for 5 min. The solvent of the reaction mixture is removed and the crude product is purified by preparative HPLC yielding 0.023 g (40.5%) of the final product. MS: M=382.2 (M+H)+

Provenance & Evidence