HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 3-(2-Benzo[1,3]dioxol-5-yl-2H-pyrazol-3-yl)-1-(3-methanesulfonyl-phenyl)-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 1,3-Benzodioxol-5-ylhydrazine | HCID 12658441 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 3-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one | HCID 59370171 | — |
| Product | 3-(2-Benzo[1,3]dioxol-5-yl-2H-pyrazol-3-yl)-1-(3-methanesulfonyl-phenyl)-1H-pyridazin-4-one | HCID 46220149 | 10% |
Reaction Steps
The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-7) and benzo[1,3]dioxol-5-yl-hydrazine (prepared from the corresponding amino derivative using sodium nitrite and tin(II) chloride as described in J. Med. Chem. 2003, 46, 4676-4686) according to the method described for Example 91 in 10% yield. MS: M=437.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4083070539704bd4b2a277f60d660f0f |
| Source note | uspto-grants-2012_05 |