HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 3-(2-Benzo[1,3]dioxol-5-yl-2H-pyrazol-3-yl)-1-(3-difluoromethoxy-phenyl)-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 1,3-Benzodioxol-5-ylhydrazine | HCID 12658441 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 1-(3-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one | HCID 59370014 | — |
| Product | 3-(2-Benzo[1,3]dioxol-5-yl-2H-pyrazol-3-yl)-1-(3-difluoromethoxy-phenyl)-1H-pyridazin-4-one | HCID 59370172 | 16% |
Reaction Steps
The product was obtained starting from 1-(3-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-10) and benzo[1,3]dioxol-5-yl-hydrazine (prepared from the corresponding amino derivative using sodium nitrite and tin(II) chloride as described in J. Med. Chem. 2003, 46, 4676-4686) according to the method described for Example 91 in 16% yield. MS: M=425.2 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-fe605f22d3804a54a919b127e1a3b22d |
| Source note | uspto-grants-2012_05 |