4-(2-Fluoro-4-methoxyphenyl)-2-hydrazinylthiazole → HCID 59370004, compound

HRID 1924572Notes

Reaction equation

HRID 1924572 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[F:25][C:26]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[CH:28][C:27]=1[C:34]1[N:35]=[C:36]([NH:39]N)[S:37][CH:38]=1>>[F:25][C:26]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[CH:28][C:27]=1[C:34]1[N:35]=[C:36]([N:39]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:2]2)[S:37][CH:38]=1

Participants

3

Reactant 2

HCID 71763354-(2-Fluoro-4-methoxyphenyl)-2-hydrazinylthiazoleHCID 593701713-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 59370004HCID 59370004, compoundYield 41%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-7) and [4-(2-fluoro-4-methoxy-phenyl)-thiazol-2-yl]-hydrazine according to the method described for Example 91 in 41% yield.

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-70d22bbadf18445c9612cafdd2f56859
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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