化工社化工社 化学情報印刷レポート · 研究参考用
Stannous Chloride → 1-(3-Difluoromethoxy-phenyl)-3-[2-(3-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | (3-Fluorophenyl)hydrazine | HCID 581026 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 反応物 | 1-(3-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one | HCID 59370014 | — |
| 生成物 | 1-(3-Difluoromethoxy-phenyl)-3-[2-(3-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one | HCID 59370130 | 37% |
反応手順
The product was obtained starting from 1-(3-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-10) and (3-fluoro-phenyl)-hydrazine (prepared from the corresponding amino derivative using sodium nitrite and tin(II) chloride as described in J. Med. Chem. 2003, 46, 4676-4686) according to the method described for Example 91 in 37% yield. MS: M=399.1 (M+H)+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08178538B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-3e17d2b54eee43508752eb02d529273e |
| 出典メモ | uspto-grants-2012_05 |